Clinical outcomes of lymph node metastases of periocular sebaceous carcinoma

Abstract

In this study, we examined the clinical outcomes of 13 cases （24％） with parotid and cervical lymph node metastases out of 54 cases of periocular sebaceous carcinoma treated at our hospital between 2010 and 2023. Parotid node metastases were found in 10 cases, a high proportion （77％）, suggesting the need for concurrent parotid node dissection when cervical lymph node metastases are found. Of the four cases with recurrence in the dissection field after surgery, three were in the group without postoperative radiotherapy, while one was in the group with postoperative radiotherapy. This finding suggests that postoperative radiotherapy to the parotid and cervical regions should be actively considered to improve regional control rates. Currently, there is no established standard treatment for distant metastasis, and the development of new therapeutic strategies remains a challenge for the future.