Summary Intraarterial infusion therapy with a reservoir system for maxillay sinus carcinomas

Abstract

We report the results of superselective intraarterial CDDP infusion therapy with an implantable reservoir system combined with radiotherapy for 5 patients with maxillary carcinomas. The catheters for intraarterial infusion were inserted from the facial artery in three patients and from the superficial temporal artery in 2 patients. The technique of catheterization from the superficial temporal artery was easier than that from the facial artery and obstruction of the artery happened in 2 patients using the facial artery. The dose of CDDP was 100mg/m² and infusion was performed from 1 to 6 times. A neutralization agent (sodium thiosulf ate) was also infused by a reservoir system implanted in the forearm. Conventional external beam irradiation was used to a total dose of 50 Gy in all patients. Complete or partial responses were obtained in 4 patients and these patients received partial maxillectomy. We conclude that the implantable reservoir system for both CDDP and STS administration is an easy, low-invasive method for intraarterial infusion therapy and is especially useful in patients with maxillary carcinomas.