Clinical observation of olfactory neuroblastoma treated at Hiroshima University Hospital between 1996 and 2006

Abstract

A clinical observation was performed on six patients with olfactory neuroblastoma initially treated at Hiroshima University Hospital between 1996 and 2006. The patients included 4 men and 2 women, aged 32 to 80. Initial symptoms were mainly nasal obstruction and epistaxis. Three patients were initially treated with craniofacial resection surgery and radiotherapy, and another three patients were treated with chemoradiotherapy alone. In the final prognosis, all three patients initially treated with surgery have lived with no evidence of disease, one of whom experienced a relapse that was completely treated with chemoradiotherapy. In the three patients initially treated without surgery, one experienced relapse and is alive with the disease, one died of the disease, and one could not be located. These results indicated that initial treatment with craniofacial resection surgery and radiotherapy was an effective treatment modality, and that treatment with chemoradiotherapy using a combination of CDDP and etoposide was an effective treatment modality in patients without surgery. This disease has been reported to have a high risk of relapse, thus long-term follow-up is necessary.