Abstract
Juvenile nasopharyngeal angiof ibroma (JNA) is characterized by aggressive growtn and hemorrhage. It is difficult to treat of the advanced stage of JNA due to its a clinical character. Recently, it has been reported that extended operations such as that for as craniof acial surgery, can be performed at an advanced stage. However, such operations have some complications and a large part of the patients with JNA are treated in adolescence. Furthermore, as it is known that JNA shows spontaneous regression, we need to consider the possibility of performing a noninvasive operation after the JNA shows spontaneous regression to some extent. In considering this issue, a case observed for a long period is very important. We had an advanced case of JNA (stage II) removed totally by endonasal approach after its spontaneous regression 8 year after first examination. We here present its clinical course and histopathological changes of sex hormones such as estradiol, progesterone, testosterone and dihydrotesterone in tumor tissue. The histopathological change of the fibroblast growth factor receptors in tumor tissue is also presented . The natural history of JNA and the treatment for JNA in advanced stage are discussed.
