Abstract
During the year of 1986 to 1994, four cases of malignant melanoma of the nose and paranasal sinuses were experienced. The four cases comprise three cases of male and one case of female. The age ranged from 18 to 78 with the mean of 47. Chief complaints were mostly nosebleed and stuffy nose with the predominance of the former . The duration from the onset of symptoms to the visit to medical institutions ranged from one month to two years with the mean of 14 months. The nasal septal mucosa was the most frequent location of the tumor. Such imaging modalities as MRI and 123I-IMP showed characteristic findings and contributed much to the diagnosis of the lesion . Definite diagnosis was done by histopathological studies including histochemical and electronmicroscopic evaluations . As for the treatment, surgeries as radical as possible were complimented with chemotherapy (DAV) and immunotherapy (Interferon). Only two cases are alive, one with tumor and one free of tumor after 12 to 14 months, one other case expired and the remaining one was lost to follow-up study.
