Abstract
The sole effect of HBO on multiple organ failure, particularly on toxic acute hepatic failure （AHF）, has not yet been clarified. The effects of HBO were studied by pathohistological observation, using rabbits which were experimentally induced into AHF by i.v. injection of D-galactosamine and the findings were compared with those of control animals.
In liver, centro-acinar degeneration, necrosis with karyorrhexis and poor leucocytic infiltration were noted in control animals. While in HBO animals, cellular structure was well preserved and many basophilic fine globular substances were seen in cytoplasma, which were identified as “Ring-mitochondria” through electron-microscopy. In control animals, cellular damage was so severe that no mitochondria could be seen. In HBO animals, degenerative changes of hepatic cell were very few and poly-nucleation suggested regeneration of damaged cell. in kidney, vacuolar degeneration was also minimal in HBO animals.
In conclusion, HBO is considered to be indicated for toxic hepato-renal failure.
