Antioxidant Promotes Wound Healing on Oral Mucosa in Diabetic Mice

Abstract

Endothelial nitric oxide synthase (eNOS) functions as a preventive for blood vessel impairment. Aberrant expression of eNOS induced by oxidative stress has been found in diabetes. In the present study, we examined whether an antioxidant promoted wound healing on oral mucosa in diabetic mice. We used N-Acetyl-L-Cystein (NAC) as an antioxidant, KK-A^y/TaJcl mice (KK-A^y) and C57BL/6JJcl mice (C57) as mouse model of diabetes and controls. The weights and blood glucose levels were higher in KK-A^y than in C57. Positive reaction for eNOS was faint in blood vessel in KK-A^y. The weight and blood glucose levels were significantly lower in KK-A^y with NAC than those without NAC. NAC induced upregulated expression of eNOS in KK-A^y. The size of wound was significantly smaller in KK-A^y mice with NAC than those without NAC. The results indicate that antioxidant may promote wound healing on oral mucosa in diabetic mice.