Abstract
The procedure of hematopoietic stem cell transplantation (HSCT) has potential to cure the hematological malignancies, based on high-dose chemoradiotherapy and allogeneic immunological effect. However, the conditioning regimen causes oral mucositis (OM) during the early periods. Methotrexate is used for the prophylaxis of acute graft-versus-host disease (GVHD), which also deteriorates the severity of OM. The immunocompromised state induces the odontogenic infections, which sometimes resulted in systemic infections. After the engraftment of neutrophil, chronic GVHD frequently affects the oral cavity, and the symptoms of dryness and soreness usually prolong throughout the lifespan. We reviewed the mechanisms and the management of oral complications after HSCT, and hope to make the progress of the mutual medical associations.
