Retrospective Study on Clinical Efficacy of Cepharanthine for Oral Lichen Planus as Determined by the Multiple Institutes Collaborative Project

Abstract

Retrospective study on clinical efficacy and safety of the Cepharanthin long-term use for the patient with oral lichen planus （OLP） was performed at 12 institutes as a multiple institution collaborative project. We examined the degree of the severity of the disease, improvement rate and the side effects of the Cepharanthin use at 4 weeks and 6 months after the prescription and at the endpoint of the Cepharanthin use for eighty OLP patients given the Cepharanthin for more than 4 weeks within a period from July 2008 to June 2013.
More than 50％ improvement rate was observed in almost all clinical types of OLP and the location of the lesions following to the Cepharanthin use. The improvement rate showed higher value at the endpoint of the Cepharanthin prescription, and long-term use revealed much higher efficacy for improving OLP. On the other hand, the dosage of the Cepharanthin showed no significant different effect for the OLP improvement. In addition, we recognized high improvement rate of the Cepharanthin use even in the case without steroid use. As a result, eighty percent of the OLP cases showed significant improvement by means of the Cepharanthin use, in addition, there was no significant adverse events following to the Cepharanthin use. From the above results, it can be concluded that the Cepharanthin has a significant efficacy for the treatment of OLP.