IgG4-related Dacryoadenitis and Sialoadenitis Associated with Minor Salivary Gland Swelling; A Case Report

Abstract

Recently Mikulicz’s disease has been considered to be the novel disease entity IgG4-related dacryoadenitis and sialoadenitis （IgG4-DS）. We herein report a case of IgG4-DS associated with minor salivary gland swelling. A 26-year-old female complained of bilateral lower lip minor salivary gland, submandibular gland and lacrimal gland swelling. Severe IgG4 positive plasmacyte infiltration was detected in the minor salivary gland, and the serum IgG4 level was markedly elevated. In addition, autoimmune pancreatitis was detected, so the patient was diagnosed with IgG4-DS. IgG4-DS occasionally associates with the minor salivary gland. Therefore, in patients with glandular swelling, IgG4-DS is an important differential diagnosis.