Journal of Japanese Society of Oral Medicine
Online ISSN : 2186-6155
Print ISSN : 2186-6147
ISSN-L : 2186-6147
Case Reports
Methotrexate Associated Lymphoproliferative Disorders Arising in the Buccal Mucosa: A Case Report
Hiroyuki SHIMIZUShutaro ISHIIHidekazu SATOHaruka FURUSAWAShin KATOTaneaki NAKAGAWAKazuyuki TSUNODA
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2019 Volume 25 Issue 2 Pages 44-50

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Abstract

Methotrexate-associated lymphoproliferative disorder (MTX-LPD), which may develop in the oral cavity, is known to be associated with the administration of methotrexate. We herein report a case of MTX-LPD that developed in the buccal mucosa. The patient was a 64-year-old woman who had undergone long-term methotrexate treatment for rheumatoid arthritis and who complained of ulcer formation in the bilateral buccal mucosa. The pathological diagnosis was diffuse large B-cell lymphoma with Epstein-Barr virus-positive cells. The lesions improved following the withdrawal of methotrexate. The development of MTX-LPD in the buccal mucosa is very rare.

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© 2019 Japanese Society of Oral Medicine
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