Abstract
This study aimed to identify the clinical features of mucous membrane pemphigoid （MMP） and pemphigus vulgaris （PV）, which are autoimmune bullous diseases, and to clarify the characteristics of the oral lesions that develop in these diseases. Data from 59 patients （27 MMP and 32 PV） were collected by retrospective chart review. The site most affected was the gingiva （93％）, showing desquamative gingivitis. 27 of the 59 （46％） patients were confirmed to have extra-gingival lesions. A statistically significant difference was found in extra-gingival lesion development between the patients with MMP （26％） and PV （63％）. Single-site oral lesions were found in 20 MMP （74％） and 12 PV （38％）. Multi-site oral lesions were observed in one MMP （4％） and 11 PV （34％）. There was a statistically significant difference in the single- or multi-site category between the two groups. In conclusion, MMP and PV should be included in the differential diagnosis for the patients with desquamative gingivitis. In patients with MMP, oral lesions were confined to the gingiva and extra-gingival lesions were uncommon. By contrast, in patients with desquamative gingivitis associated with PV, extra-gingival lesions were found at multiple sites.
