Abstract
We report of two male patients with RS3PE syndrome which began with an acute onset of polyarthralgia and pitting edema during the course of treatment for spine-related pain symptoms of the upper and lower extremities. RS3PE syndrome was diagnosed from the patients' physical and laboratory fi ndings. In both patients, therapy with low doses of oral steroids resulted in prompt remission of joint pain and edema. Increased awareness of RS3PE syndrome as a collagen disease-like clinical entity resembling rheumatic arthritis may be warranted.
