Three cases of postdural puncture headache successfully treated with pregabalin

Abstract

We report three cases of postdural puncture headache (PDPH) that were successfully treated with 150 mg/day of pregabalin. They were women in their 40s and 50s, and epidural anesthesia was performed for their anesthetic managements. On postoperative day 1 (POD1), they developed a headache in the upright position. They received pregabalin 75 mg/day from POD3. After the dose was increased to 150 mg/day, the headache improved. The results reported here indicate that pregabalin might become a new option for the treatment for PDPH.