Pamidronate was effective for intractable complex regional pain syndrome type I: A case report

Abstract

Pamidronate, which strongly suppresses osteoclast-induced bone resorption, was effective for an intractable CRPS type I case. The patient was a 30-year-old woman who had injured her left ankle in a traffic accident, and developed CRPS type I 8 years ago. Her symptoms were refractory to conventional therapies, including nerve blockades, lumbar sympathetic blockade, spinal cord stimulation, and physical therapy. She was treated by an intravenous administration of pamidronate, and the VAS decreased and ROM improved.