Abstract
Background: In the present study we examined an effect of superior cervical ganglionectomy on gastric ulcer formation in rats.
Material and Methods: Rats were classified into 4 groups: right ganglionectomy (RG) group, left ganglionectomy (LG) group, bilateral ganglionectomy (BG) group and control (C) group. Using indomethacin, alcohol or stress, gastric ulcers were induced in all rats; the ulcers were measured according to the ulcer index, and gastric secretion in all groups were measured. We also used immunohistochemical techniques to determine the numbers of sympathetic nerve in gastric mucosa.
Results: The ulcer index formed by indomethacin in the LG group was significantly less than that in the RS group, while in BG group it was significantly less than in RS and C groups. The ulcer index value formed by stress in LG group was significantly less than that in RG and C groups, while in the BG group it was significantly less than in C group. Gastric secretions were not different between all groups. Gastric mucosal neurofibers were reduced in LG and BG groups.
Conclusion: Superior cervical ganglionectomy results in a decrease in gastric ulcer formation induced by indomethacin and stress. This action may be caused by maintaining microcirculation in gastric mucosa.
