L-Isoleucine in Enteral Nutrition is Useful for Glycemic Control and HbA1c in Type 2 Diabetic Rats.

Abstract

We evaluated the effect of a diet containing L-Isoleucine for the inhibition of hyperglycemia and the increase of hemoglobin A1c (HbA1c). The normal rats what were given a liquid diet containing 0.5 and 1.0g of L-Isoleucine per 100kcal developed dose-dependent suppressed hyperglycemia compared with the control group. Moreover, compared with the control diet, the type 2 diabetic rats (ZDF) given a diet containing 0.5g of L-Isoleucine experienced a slower increase of HbA1c levels during the six week feeding period. These results indicate that the addition of L-Isoleucine to diet may have the same effects for diabetes patients.