Fabrication of Biodegradable Core-Shell Micro/Nanoparticles

Abstract

Biodegradable core-shell particles were successfully obtained through a novel surfactant-free emulsification method. The particles were formed by interfacial interaction between poly (lactic acid) core and hydroxyapatite shell. The precipitated calcium phosphate played a role as stabilizer for microsphere fabrication. The method can be modified to produce various morphological particles, such as porous, hollow and nano-sized particles. The developed biodegradable particles would be expected to be used for a wide range fields as biocompatible and environmentally friendly particles.