2020 Volume 56 Issue 1 Pages 49-54
Objective: To investigate the outcomes of pregnant women complicated with mental disorders.
Methods: A retrospective investigation of 146 singleton pregnancies complicated with mental disorders were performed between January 2013 and December 2017 at our institution. Mental disorders were diagnosed according to the International Classification of Diseases, 10th version（ICD10）.
Results: Among the 146 women, 36（24.7％）relapsed in perinatal period, of which 32 during pregnancy, 2 during labor, and 2 during postpartum. Seven cases needed psychiatric admission. Eighty-three women were medicated before pregnancy. Among 49 who maintained their medication throughout their pregnancy, 7（14％）relapsed compared with 14（41％）of the 34 women who discontinued or reduced medication. Women who discontinued or reduced medication relapsed significantly more frequently over the course of their pregnancy compared with women who maintained their medication（odds ratio, 3.3; 95％ confidence interval, 1.1-10.2; P ＜ .001）. Among the 145 neonates born in the institute, 29（20％）required pediatric hospitalization, of which 5 for neonatal withdrawal syndrome, 9 for preterm birth and low birth weight, 9 for respiratory failure, 4 for infection, 2 for nursery disability, 1 for neonatal asphyxia, and 1 for meconium aspiration syndrome.
Conclusion: The pregnant women with mental disorders have a potential risk for relapse in perinatal period, especially according to discontinuation or reduction of medication.
