A case report of pregnancy complicated with stage IC ovarian cancer

Abstract

 For the case of ovarian cancer during pregnancy, it is necessary to select examinations and treatments in consideration of both maternal prognosis and effects on the fetus. Here, we report two cases of ovarian cancer diagnosed during pregnancy. The first case was 37-year-old and was diagnosed with low grade left serous carcinoma at 5 weeks of gestation. At 8 weeks of gestation, a left salpingo-oophorectomy, omentectomy, right ovarian biopsy, and ascites cytology were performed and was diagnosed as stageIC2. She continued pregnancy without additional treatment, and vaginal delivery at 41 weeks in gestation. No recurrence have occurred in the first 6 years after initial treatment. The second case was 33-year-old and was diagnosed with left mucinous carcinoma stage IC2（Grade 2）at 13 weeks gestation. After 3 courses of chemotherapy using paclitaxel and carboplatin at 16, 19 and 22 weeks of gestation, cesarean section and staging laparotomy was performed at 37 weeks of gestation. Three courses of postoperative chemotherapy using paclitaxel and carboplatin was also performed, and no recurrence or complications have occurred in the 2 years after the treatment.

 There were no notable abnormalities in pregnancy in either case, and both children had a good short-term prognosis.

 There are few a decade reports of stage IC epithelial ovarian during pregnancy. We report the clinical characteristics of these patients and provide a literature review.