Cases of diabetes during pregnancy causing fetal polyuria and polyhydramnios

Abstract

 Diabetes insipidus occurs very rarely during pregnancy. The prevalence of this disease is estimated to be about 4 per 100,000 pregnancies. This is caused from the transient increase of placental production of vasopressin. Only one case is reported fetal polyuria and polyhydramnios induced by maternal diabetes insipidus in the past. We are now reporting the second case of diabetes insipidus during pregnancy causing fetal polyuria and polyhydramnios. Furthermore, in our report, immunohistochemically staining of the placenta was performed using an anti-vasopressin antibody, confirming the strong expression of vasopressin’s in chorionic villi. There are several reports of diabetes insipidus during pregnancy, but it is unclear why fetal polyuria and polyhydramnios occurred only in our previous reports and in our case. Diabetes insipidus during pregnancy can occur consecutive, and in our case, if the disease recurs in the next pregnancy, more detailed studies show the exact physiological role of placental vasopressin’s and pathology of this disease may be revealed.