A case of maternal cytomegalovirus infection with relapse and exacerbation of ulcerative colitis

Abstract

 Maternal infection with cytomegalovirus（CMV）during pregnancy results in a CMV infection rate of 0.3% in the delivered child, which can cause mental retardation, developmental delay, and hearing loss. This paper reports a case in which the mother was diagnosed with CMV infection due to ulcerative colitis（UC）during pregnancy, and the child was diagnosed with asymptomatic congenital CMV infection. The patient was a 31-year-old gravida 2 para 1 woman with concomitant UC. UC symptoms re-emerged around the 28th week of pregnancy, and she started taking oral mesalazine from the 31st week of pregnancy. She was diagnosed with CMV infection via a blood test conducted to exclude CMV enteritis. The patient underwent vaginal delivery at 38 weeks of pregnancy, and her son was diagnosed with asymptomatic congenital CMV infection. Valganciclovir was administered for 6 weeks from age 6 days, and the urine CMV was negative. Mental development was satisfactory in the first year of life. In this case, we were able to diagnose and treat the child promptly for congenital CMV infection after birth.