2023 Volume 59 Issue 3 Pages 311-316
［Objective］Ulcerative colitis（UC）has been reported to increase the risk of adverse pregnancy outcomes, such as cesarean section（CS）, preterm delivery, low birth weight（LBW）, and congenital malformations; however, only a few studies have examined Japanese pregnant women with UC with total proctocolectomy（TP）. The aim of this study is to clarify pregnancy outcomes among pregnant women with UC with TP compared with those without TP at our department.
［Methods］We retrospectively investigated the data of pregnant women treated at our department between 1999 and 2018. We compared outcomes between patients with TP（TP group）and without TP（non-TP group）. In addition, we compared these outcomes with the control group without medical complications including UC, which was extracted by propensity score matching based on maternal age and pregnancy history.
［Results］We analyzed 23 pregnancies of 15 women with UC, including seven pregnancies of four women with TP（TP group）and 16 pregnancies of 11 women without TP（non-TP group）. Preterm delivery occurred in one pregnancy（14％）in the TP group and in two（13%）in the non-TP group. CS was performed in three pregnancies（43%）in the TP group and two（13%）in the non-TP group. Perinatal deaths occurred in two pregnancies（13%）from the non-TP group, also one pregnancy（0.9%）from the control group（115 pregnancies）. Statistical differences were not observed for all outcomes between the TP and non-TP groups.
［Conclusion］This study did not report an increased risk of adverse pregnancy outcomes in pregnancies with TP history compared to pregnancies of UC patients without TP.
