A case of Central pontine myelinolysis thought to be caused by magnesium sulfate

Abstract

 Central pontine myelinolysis（CPM）is a disorder usually caused by rapid sodium compensation in hyponatremia. CPM related to pregnancy is most often reported in cases of severe hyperemesis gravidarum, and some cases have been reported in association with Wernicke’s encephalopathy. CPM unrelated to hyponatremia has also been reported, and myelinolysis is thought to be caused by damage to rare process glial cells due to hyperosmotic stress. In this case, involuntary movements of the right lower extremity appeared while magnesium sulfate was being administered for impending preterm labor, and the symptoms improved with discontinuation of magnesium sulfate and vitamin supplementation.