2025 Volume 61 Issue 1 Pages 174-179
Silver-Russell syndrome（SRS）is a congenital imprinting disorder characterized by severe fetal growth restriction and postnatal growth retardation, relative macrocephaly, body asymmetry. Most causes of SRS are hypomethylation of the imprinting center region 1（ICR1, H19/IGF2: IG-DMR）. We report a case of SRS in only one child who shared the placenta of dichorionic triamniotic triplets. The patient’s mother was 33-year-old nulliparous woman. She was diagnosed dichorionic triamniotic triplets and referred our hospital at 11 weeks of gestation. At 21 weeks of gestation, fetal growth restriction（FGR）was observed in both fetuses sharing one placenta. At 30 weeks of gestation, an emergency cesarean section was performed due to increased uterine contractions and maternal liver dysfunction. Her second child was suspected of having SRS due to postnatal growth retardation and distinct physical features characteristic of the condition, and the diagnosis was definitively confirmed through methylation analysis. It only occurred in one child of the triplets, it was possible that the epigenetic events occurred after the embryo divided into two inner cell masses, or that the twins were dizygotic monochorionic twins.
