Abstract
Elective colon surgery is common in pediatric surgery, in which postoperative complications are encountered more frequently. In colonic operations, it is said that the reduction of colonic microflora by means of oral admistration of some antibiotics is useful for prevention of postoperative complications. Colonic microflora are formed of aerobic and anaerobic orgnisms, which suggests that preoperative oral antibiotics must have the susceptibility against the both organisms. Gentamicin is the most effective agent against aerobic organisms and Chloramphenicol, Lincomycin and Clindamycin are effective against anaerobic Bacteroides fragilis by the studies at our department. Recently it was found that Metronidazole has the good susceptibility against Bacteroides fragilis. The alteration of fecal microflora among the three groups was examined; prepared with Kanamycin, Gentamicin and Clindamycin, Gentamicin and Metronidazole. In this study, a significant reduction of aerobic fecal microflola is achieved in the group receiving Gentamicin and Metronidazole. The incidence of postoperative complication in patients prepared with Gentamicin and Metronidazole is significantly lower than that in those prepared with Kanamycin. It is believed that the combination of Gentamicin and Metronidazole is the most effective antimicrobial agents when given by mouth before the elective colon surgery for prevention of postoperative complication.
