1983 Volume 19 Issue 1 Pages 83-88
A 2 year and 6 month old female is presented with yolk sac tumor originating from the vagina. The patient underwent hysterectomy, vaginectomy and dissection of the regional lymph nodes. Chemotherapy using actinomycin D, adriamycin, vincristine and cyclophosphamide (T-2 protocol) has been carried out with radiotherapy. Serum a-fetoprotein (AFP) level once decreased to reach the normal range after operation, but elevated again during the interval period of chemotherapy. However, AFP has decreased rapidly responding to resumption of the therapy. The patient has been free from recurrence to date for 2 years and 10 months after operation. Combination therapy with operation, chemotherapy and radiotherapy is needed in treatment of yolk sac tumor. Especially T-2 protocol is very effective.
