Abstract
During a period from 1981 to 1983, three infants with intractable hypoglycemia have undergone an extensive pancreatic resection for nesidioblastosis at the Kobe Children's Hospital. In two patients, the initial extensive resection of the pancreas (85-90%) was successful for the management of hypoglycemia. However, one patient required two additional resections of the pancreas for persistent hypoglycemia. At the third operation, total pancreatic tissue was removed, which was successful to stabilize the blood sugar level. The experience in these three patients has provided the following conclusions; (1) An extensive resection of the pancreas (90%) should be carried out at the initial operation. (2) The postoperative cource should be carefully monitored by frequent measurement of blood sugar level. (3) When hypoglycemia is persistent, a total pancreatectomy should be carried out.
