Abstract
Angiotensin II induced hypertensive chemotherapy has not been reported in malignant solid tumor of childhood. The purpose of this paper is to determine how to combine angiotensin II and cyclophosphamide which is masked compound, because cyclophosphamide has been frequently used for treatment of malignant solid tumor in childhood. Then the concentration of active type of cyclophosphamide in blood and tumor tissue were measured sequentially after injection of inactive type of cyclophosphamide intra venously to A/Jax mice bearing C-1300 neuroblastoma. The peak time which appeared active type of cyclophosphamide in blood and tumor tissue of A/Jax mice was 60 minutes after the injection of inactive type of cyclophosphamide. When angiotensine II induced hypertension was continued during 60 minutes after the injection of inactive type of cyclophosphamide followed above data, the effect of cyclophosphamide to C-1300 neuroblastoma in A/Jax mice were enhanced. This combination chemotherapy of angiotensin II and cyclophosphamide was applied to a 9 year old girl with rhabdomyosarcoma, who had lung metastasis and multiple dissemination of abdominal cavity. Followed this combination chemotherapy of angiotensin II, cyclophosphamide, vincristine and actinomycine D, her abdominal circumference was decreased sooner than after simple type of VAC chemotherapy.
