Abstract
Splenic autotransplantation after splenectomy was successfully performed in two patients (aged two and fifteen) with idiopathic thrombocytopenic purpura (ITP). Following the splenectomy, ten fragments of thinly sliced tissue from a quarter of the spleen was implanted into an omental pouch. The regeneration of implanted splenic tissue was confirmed by radiocolloid localization of Sn Scintiscan. The regenerated spleen did not produce the thrombocytopenia. Furthermore, B-cell lymphocyto reaction to PHA and concanavarin A which were decreased after operation returned to normal after regeneration of splenic tissue. Our results may suggest that splenic autotransplantation after splenectomy could be a new therapeutic method for the patient with severe ITP.
