Abstract
We treated three patients with advanced stage neuroblastoma with cisdiamminedichloro-platinum (CDDP), high-dose cyclophosphamide, vincristin, and adriamycin. The patients were 3 years 9 months, 1 year 11 months, and 5 years 11 months of age at diagnosis respectively, In summary 1) These combination chemotherapy was quite effective for the initial remission induction of the three cases, 2) The CDDP was also effective for the treatment oi metastatic bone lesion of one of the cases. 3) Major side effects of this regimen were electrolyte abnormalities, renal dysfunction and severe diarrhea, all of which were well-tolerated with the supportive care. 4) The profound bone marrow suppression was associated with this therapy, and disturbed the pursuit of the regimen. We prophylactically applied leukocyte rich blood transfusion, which helped to complete the schedule. 5) We concluded that further aggressive cure-oriented therapy such as combination of delayed-primary surgery, and autologous or allogeneic bone marrow transplantation should be considered after achievement of complete remission with such an intensive chemotherapy.
