Evaluation of Renal Function Tests in Patients With Advanced Neuroblastoma Receiving cis-Diamminedichloroplatinum (II)

Abstract

BUN, serum creatinine, creatinine clearance, fractional excretion of sodium (FENa), serum β_2-microglobulin, urinary β2-microglobulin, and urinary N-acetyl-β-D-glucosaminidase (NAG) were measured in eight patients with advanced neuroblastoma who were receiving cis-diammine-dichloroplatinum (II) (CDDP). These parameters changed within the first week after CDDP treatment. Increased urinary excretion of NAG was observed untill the second week had passed after CDDP administration. But the value of each parameter on the 3rd day after CDDP administration was not significantly correlated with the cummulated dose of CDDP administered. These results indicate that these parameters show acute renal injury due to CDDP treatment, but the long-term latent nephrotoxicity of CDDP cannot be predicted from these parameters.