Abstract
The association between neuroblastoma and the subunit B of creatine kinase (CK-B) was investigated to assess the possibility of the role of CK-B as a tumor marker for neuroblastoma. With the use of a sensitive solid-phase sandwich enzyme immumoassay system, the cocentration of serum CK-B was measured in 47 patients with inguinal hernia under 10 years old for normal controls, and in 29 patients with neuroblastoma. The CK-B concentration was elevated on 66% of the neuroblastoma patients. The relationship between the prognosis of neuroblastoma patients and the serum CK-B level was found statistically significant. These data suggest that CK-B is an useful serum marker for prediction of prognosis, diagnosis, and monitoring the effectiveness of therapy.
