Evaluation of Stability of DNA Histogram Obtained from Patients With Neuroblastoma

Abstract

In order to evaluate the stability of DNA histograms obtained from patients with neuroblastoma, 512 samples from 62 patients were examined. In almost all patients, every DNA histogram from different tumor portions had the same DNA index. Heterogeneity was detected only in 3 patients. To evaluate whether DNA ploidy has the potential to change its type with progression or not, we investigated DNA histograms obtained at different periods from the same patients. No change of DNA ploidy was detected in this study. In conclusion, DNA histogram is considered to be stable in neuroblastoma.