Abstract
Recently the effective chemotherapy against hepatoblastoma have been reported by American and European group studies. In this paper three patients with unresectable hepatoblastoma on admission were reported. They were treated by the protocol of Japnaese Study Group for Pediatric Liver Tumor (J ・ PLT), including THP-Adriamycin and Cisplatin. Following either 3 or 4 courses of chemotherapy, tumor sizes, evaluated by magnetic resonance imaging (MRI) , reduced to 64, 68 and 46%, respectively. In addition, serum levels of α-fetoprotein decreased to 0.1, 0.6 and 1.6%. Tumors were totally resected by the second look operation. At present (April, 1994), theree patients are in tumor free conditions for 26, 20 and 16 months after their operations. Although the observation periods were not long enough, J ・ PLT protocol is indicated to be effective to patients with hepatoblastoma.
