Abstract
The aim of this study is to evaluate the efficacy of fine emulsified fat in the enteral nutrition. The study was performed in 8 weeks old rats with obstructive jaundice (J group) and without jaundice (sham operation group ; S group). Rats in every group were fed with isocaloric diet (60kcal/day) consisted of carbohydrate, protein, minerals and vitamins. Fat modules were supplemented as follows. The emulsified soy bean oil (10%, particle sizes : 0.1-0.3 micrometer) was given in J (JE) and S (SE) groups. The commercial soy bean oil (unemulsified) was given in J (JB) and S (SB) groups. These fat modules accounted for 13% of the total calorie in every diet. All nutrients were administered into the stomach via a gastric tube for 28 days. Values of fatty acids in plasma total lipid fraction were determined by gaschromatography. The emulsified fat was as well absorbed in JE group as in SE group. While the unemulsified fat was markedly less absorbed in JB group. A typical pattern of fatty acid deficiecy with reduction in linoleate and arachidonate, and increase in palmitoleate, oleate and 5, 8, 11 eicosatrienoate in total lipid fraction of plasma were observed in JB group. These results showed that the emulsified fat, in contrast with the unemulsified fat, is well absorbed from the intestine in jaundiced rats. I suspect that the fine emulsified fat is effective as a fat module of the enteral nutrition in patients with insufficient bile excretion.
