Abstract
Castleman’s disease is a polyclonal lymphoproliferative disorder, and pediatric cases are rare. Herein, we report the case of a 7-year-old boy with unicentric Castleman’s disease of the mediastinum. He was referred to our hospital owing to fever of unknown origin and high serum CRP level. A CT scan revealed an enhanced lymphadenopathy of 2 × 4 cm size in the mediastinum, and the lesion showed an increased FDG uptake in FDG-PET (SUVmax: 3.586). We completely resected the lesion by thoracoscopic surgery. The diagnosis of hyaline-vascular-type Castleman’s disease was established by histopathological examination. His fever resolved and the CRP level became normal immediately after the operation. He is free of disease 9 months after the surgery. Although unicentric Castleman’s disease is rare, it is important to consider it in the differential diagnosis of localized lymphadenopathy, and when suspected, complete resection is required.
