Abstract
Lymphatic malformation (LM) is a disease commonly encountered in the field of pediatric surgery and generally treated by sclerotherapy with OK-432, which is the only treatment approved for this disease by the health insurance system in Japan. Although the OK-432 injection sclerotherapy is effective and less invasive, in patients in whom it failed, another treatment option is required. We report two successful cases of sclerotherapy with ethanol for LM resistant to OK-432 injection sclerotherapy. Case 1: A 15-year-old girl with LM in the right neck was treated with OK-432 injection sclerotherapy seven times, but her LM tended to enlarge. After ethanol sclerotherapy, her LM decreased in size in two weeks. Case 2: A 20-year-old female with LM in the right neck was treated with OK-432 injection sclerotherapy twice, followed by resection, but her LM remained. After ethanol sclerotherapy, her LM decreased in size and remained shrunk. Ethanol sclerotherapy could be a second-line treatment for LM resistant to OK-432 injection sclerotherapy.
