A Case of Juvenile Granulosa Cell Tumor of the Ovary Detected Owing to Precocious Puberty

Abstract

We report the case of a 7-year-old girl who presented with precocious puberty caused by juvenile granulosa cell tumor of the ovary. Her symptoms were premature thelarche at pre-elementary school age and vaginal bleeding and increased somatic growth at the time of diagnosis. Abdominal ultrasonography demonstrated a 14 × 10 × 7 cm lesion occupying most of the abdominal cavity. MRI showed a mixture of solid and cystic lesions. The preoperative diagnosis was juvenile granulosa cell tumor or dysgerminoma. Right salpingo-oophorectomy was performed. Contralateral adnexa of the uterus was normal and ascites cytology showed negative results. Histopathological analysis revealed juvenile granulosa cell tumor with an intact capsule. The FIGO classification was Stage Ia. Her postoperative clinical course was uneventful for 12 months. No adjuvant chemotherapy was administered.