Isolated Neurofibroma of the Colon of a Child That Was Not Associated With Neurofibromatosis Type 1 (NF1): Case Report

Abstract

We describe a rare case of isolated neurofibroma of the colon in a child that was not associated with neurofibromatosis type 1 (NF1). Abdominal ultrasonography demonstrated intussusception in an 11-year-old girl who was referred to our hospital with intermittent abdominal pain. An enema study indicated intussusception of the ascending colon, and abdominal computed tomography confirmed that it was caused by a mass of 4 cm diameter. Therapeutic enema was successful, but abdominal pain recurred 10 hours later, so the patient was treated by emergency partial colectomy. The resected specimen comprised a soft, elastic tumor that was immunopositive for the S-100 protein and CD34, indicating neurofibroma. She was discharged six days after surgery and followed up at our hospital. This is the first case of neurofibroma of the colon of a child that was not associated with NF1. Special attention is required during the management of neurofibroma, because the treatment depends on whether it is associated with NF1 or not.