Experience of Tsudosan Usage, a Traditional Japanese Kampo Medicine That Reduces Subcutaneous Tissue Swelling and Pain Resulting From Trauma or Surgery, in Two Pediatric Patients

Abstract

Introduction: Tsudosan (TJ-105, Tsumura & Co., Tokyo), a traditional Japanese Kampo medicine, is indicated for treating blood stasis caused by microcirculation disturbances. We report on the effectiveness of TJ-105 in treating patients with traumatic or postincisional subcutaneous swelling and pain. Case 1: A 14-year-old boy was admitted to our hospital with traffic injuries. He had contusions in his left arm and leg. His left 7th rib was fractured. He complained of pain at the injury sites and headache. TJ-105 (5.0 g/day in 2 divided doses) for contusion and TJ-17 (5.0 g/day in 2 divided doses) for headache were begun on day 1. The patient was discharged on day 3 after injury because his condition improved. The swelling and pain decreased on day 6; therefore, TJ-105 and TJ-17 were taken at a reduced dose (2.5 g/day) for 7 days. His injury site swelling disappeared on day 13. Case 2: A 10-year-old boy was admitted and treated in our hospital for a subcutaneous facial tumor. The tumor was confirmed be Kimura’s disease, and thus resected. TJ-105 (2.5 g/day) was administered to prevent subcutaneous swelling. He took TJ-105 from POD 2 to POD 7. The swelling at the incision site decreased soon after taking TJ-105 and it disappeared by POD 9. There were no side effects in both cases. Conclusion: From our experience, TJ-105 improved the patients’ conditions by reducing the subcutaneous swelling and pain caused by injury or incision.