2021 Volume 57 Issue 7 Pages 1133-1140
We present the case of a female patient with hepatoblastoma associated with trisomy 18, who was successfully treated using a combination of chemotherapy and surgical resection. She was born after 37 weeks of gestation with a body weight of 1,470 g and was diagnosed after birth as having trisomy 18 and esophageal atresia with tracheoesophageal fistula. On her first day of life, she underwent primary repair of the esophageal atresia at a previous hospital. At the age of 12 months, computed tomography revealed a tumor at the right hepatic posterior segment area of the liver. Thereafter, she was transferred to our hospital. The liver tumor was diagnosed as hepatoblastoma because the serum alpha-fetoprotein (AFP) level was as high as 16,671 ng/ml. The tumor was classified as stage I hepatoblastoma on the basis of her pretreatment extent in accordance with a disease system classification. Cisplatin was administered as her preoperative chemotherapy to reduce the size of the tumor before surgery. She underwent resection of the right hepatic posterior segment at the age of 1 year and 2 months. The postoperative course was uneventful, and adjuvant chemotherapy was added. She returned to the previous hospital 37 days after her operation. Unfortunately, she died of viral pneumonia without any recurrence of hepatoblastoma at the age of 2 years and 10 months.
