A Case of Beckwith–Wiedemann Syndrome With Hepatoblastoma in Infancy Followed by Fibroadenoma of the Breast in Adolescence

Abstract

Beckwith–Wiedemann syndrome (BWS) is a congenital disorder with a variety of symptoms such as umbilical hernia, giant tongue, hemihypertrophy, and neonatal hypoglycemia. One of the characteristics of BWS is a tendency to develop fetal malignant tumors such as hepatoblastoma and nephroblastoma. We have experienced a case of hepatoblastoma in infancy followed by fibroadenoma (FA) of the breast during adolescence. When following children with BWS, the possibility of FA as well as malignant tumors should be kept in mind.