2023 Volume 59 Issue 6 Pages 1014-1018
A 9-year-old boy complaining of back pain was referred to our hospital. An abdominal CT examination revealed a low-contrast-enhancement tumor (20 mm in diameter) with small calcification in the lower pole of the left kidney. First, we performed a left lower hemi-nephrectomy. A rapid pathological examination revealed renal cell carcinoma. Although no obvious tumor exposure was observed at the resection margin, a left total nephrectomy was then carried out owing to an insufficient margin from the tumor to the renal hilum. The pathological diagnosis was papillary renal cell carcinoma with metanephric adenofibroma. BRAF V600E mutation was identified in the tumor by genetic analysis. The tumor was classified as stage I, and no further treatment was performed. No recurrence was observed during the follow-up period of six months. Pediatric renal cell carcinoma associated with the BRAF mutation is extremely rare, but this gene mutation is frequently detected in metanephric tumors. Therefore, this carcinoma might be divided from metanephric tumors. A case of pediatric renal cell carcinoma associated with the BRAF mutation was reviewed with some published reports.
