Abstract
It is known that localized pathological conditions of the lung can be detected by bronchoalveolar lavage fluid (BALF). We have produced granulomatous interstitial pneumonia in rabbit, which was histopathologically quite similar to hypersensitivity pneumonitis in human, when OA+MDP was given by repeated aspiration, and observed the transition of cellular components in BALF and specific anti OA antibody titers over the passage of time. As compared with a group that was made to inhale saline, the total number of cells in BALF significantly increased a week after inhalation of OA+MDP. Although lymphocytes and neutrophils notably increased in BALF, alveolar macrophages that also increased showed a variety of pictures of irregular sizes, and these cells in BALF continued to increase even 4 weeks after inhalation. Concerning specific anti OA antibodies in BALF, IgG antibody in the group that inhaled OA+MDP showed, in the first place, an appreciable increase a week after inhalation, compared with that of the saline group, followed by an increase of IgG antibody in order. It was suggested from analysis of BALF that MDP given by aspiration acts as an adjuvant in the induction of ganulomatous pneumonia without waning.
