Abstract
To assess the reconstruction of bronchial blood flow in lung allografts with immunosuppression by FK-506, left lung allo-transplantation was performed in 26 adult mongrel dogs. The recipient dogs were administered FK-506 intramuscularly at a dose of 0.1mg/kg/day. Bronchial mucosal blood flow(BMBF) at the second carina in the graft lungs and the carina in the recipient was measured with an Advance Laser Flowmeter. The L/C ratio (blood flow at the second carina of a graft/blood flow at the carina of the recipient) was 1.05±0.24(n=11) in normal lung of control dogs. The L/C ratio decreased to 0.57±0.09(n=9) after transplantation, and recovered to 1.03±0.10(n=7) 3 weeks after surgery. During rejection, the L/C ratio was significantly lower in severe rejection than mild rejection or normal lungs 3 weeks after transplantation: 0.56+0.33(n= 2) V.S. 0.98±0.11(n=4) or 1.03±0.10(n=6) (p<0.01). We concluded that reconstruction of the BMBF in canine lung allografts with immunosuppression of FK 506 is accomplished 3 weeks after transplantation, and the bronchial circulation is not influenced in allograft lungs with mild reiection but influenced in allograft lungs with severe rejection.
