Gene Therapy for Lung Cancer Using p53 Adenovirus Vector (Symposium 7)

Abstract

Three patients with non-small cell lung cancer were treated by gene therapy using p53 adenovirus vector (Ad-p53) in Tokyo Medical University Hospital. Case 1: A 68-year old male with c-stage IIIB adenocarcinoma in the right upper lobe was treated with gene therapy combined with chemotherapy of cisplatin (CDDP), because the prior chemotherapy had resulted progressive disease (PD). Two cycles of gene therapy suppressed the tumor growth and the therapeutic results were evaluated as stable disease (SD). Case 2: A 61-year old male with c-stage IIIB squamous cell carcinoma of the right upper lobe bronchus was treated with gene therapy combined with chemotherapy of CDDP for a regrowing tumor after chemo-radiotherapy. The therapeutic effect was evaluated as SD. Case 3: A 62-year old male with c-stage IIIB squamous cell carcinoma in the right upper lobe was treated with Ad-p53 for a relapsed tumor after chemoradiotherapy. The therapeutic effect of 4 cycles of gene therapy was SD. In these 3 patients no serious adverse events concerning administration of the vector were observed. One patient (case 1) has been surviving for 32 months after gene therapy without tumor growth or a distant metastasis.