Abstract
Background. Although surgical resection is a standard treatment for bronchial carcinoid, bronchoscopic approaches such as laser coagulation, photodynamic therapy, and electrocautery for intraluminal typical bronchial carcinoid (ITBC) are also useful. We here report a case with ITBC that was well controlled by interferon-alpha (IFN-alpha) as adjuvant therapy for hepatocellular carcinoma (HCC) followed by bronchoscopic hot biopsy. Case. A 59-year-old man, for whom IFN-alpha was administered as adjuvant therapy after resection of HCC, complained of bloody sputum. Computed tomography (CT) scan of the chest revealed atelectasis of the right middle lobe. A submucosal tumor occluding the middle lobe bronchus was observed bronchofiberscopically and was histologically diagnosed as ITBC by transbronchial biopsy. Conventional surgical resection was considered for treatment, but close follow-up by bronchoscopy was selected because of the poor prognosis of HCC and the slow growing nature of ITBC. Thereafter, the ITBC became smaller. The remaining tumor was completely resected by subsequent bronchoscopic hot biopsy. One year and 6 months after completing IFN-alpha therapy, the patient remains well without evidence of local recurrence or distant metastasis. Conclusion. IFN-alpha administration and bronchoscopic hot biopsy were effective for the treatment of ITBC.
