A Case of Trachea-Bronchial-type Amyloidosis in Which an Obstructive Ventilatory Defect Was Improved by External Beam Radiotherapy

Abstract

Background. Limited-stage pulmonary amyloidosis is a degenerative disease that causes amyloid deposition under the mucosa of trachea, bronchus, and lung. Case. A 66-year-old woman was diagnosed with intractable asthma and repeated pneumonia at another facility. She was referred to our hospital for a closer inspection. Bronchial stenosis was found on chest computed tomography, and rhonchi were prolonged on chest auscultation. We performed bronchoscopy. A yellow diffuse nodal lesion was detected from the trachea to the right and left bronchus mucosa, with constriction. A transbronchial biopsy showed non-AA amyloidosis, and a biopsy specimen was obtained from the site. The patient's other organs did not have any significant findings. The patient's diagnosis was revised to localized tracheobronchial amyloidosis. External beam radiotherapy (EBRT) was performed for the trachea-bronchial lesion, and the patient's symptoms were improved. Conclusion. We reported the effectiveness of EBRT for trachea-bronchial amyloidosis. We have now added this case and report the consideration of the philology.