2021 Volume 43 Issue 5 Pages 473-479
Case. A 62-year-old man with lung squamous cell carcinoma (cT2bN3M0, cStage IIIB according to the 8th edition of Union for International Cancer Control) received carboplatin+nab-paclitaxel treatment in combination with radiation therapy (30 Gy) to improve airway constriction; however, pleural dissemination emerged. The chemotherapy regimen was switched several times based on tumor progression, and he received eighth-line S-1 treatment four years after the initial diagnosis, by which point the enlargement of the primary tumor had resulted in right main bronchial obstruction. Therefore, endobronchial tumor debulking was performed, and an uncovered stent was inserted into the right superior lobar bronchus through the right main bronchus. However, chest computed tomography and bronchoscopy performed one month later revealed in-stent tumor infiltration. The uncovered stent was replaced with a covered stent, and photodynamic therapy (PDT) was initiated for the tumor mass surrounding the right main bronchus. He received nineth-line vinorelbine treatment with a good performance status. Conclusion. Endobronchial interventions, such as tracheobronchial stents, and PDT play a pivotal role in the treatment of lung cancer with central airway constriction, helping to preserve the performance status of patients who can be treated with effective chemotherapy regimens.
